Jason L. Sperry, MD, MPH is an Assistant Professor with a primary appointment in the Department of Surgery, Division of Trauma and General Surgery and secondary appointments in the Department of Critical Care Medicine and the Clinical and Translational Science Institute at the University of Pittsburgh. He is a physician trained in general surgery and surgical critical care with a masters’ degree in public health. His research focuses on elucidation of the mechanisms that are responsible for sex based outcome differences following injury. The innate immune response following injury is a complex process whose intensity can be modulated at unique signaling points by different mediators with potential interaction. His work has helped demonstrate that, in addition to sex-hormone differences, alternative mechanisms including X-chromosome polymorphisms may alter the inflammatory response post-injury and may be responsible for differential outcomes across sex.