Pittsburgh Surgical Outcomes Research Center
Transforming the conduct of clinical research


Predictors of Complicated Clostridium difficile Infection

An analysis of all patients at UPMC Presbyterian Shadyside over the past 10 years to develop a demographic profile of patients with Clostridium difficile infection, as well as to identify predictors of a complicated disease course. The study will also include the development of computable phenotypes of disease (phekb.org) for both routine and complicated Clostridium difficile infection.

Identifying clinically relevant variables associated with early versus delayed postoperative venous thromboembolic disease.

Venous thromboembolic disease (VTE), which encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and preventable source of post-operative morbidity and mortality. The high incidence of VTE reflects both underutilization of standard thromboprophylactic regimens and also an incomplete understanding of how surgery and critical illness affect the risk of post-operative VTE over time.