Dr. Brian S. Zuckerbraun's lab primarily investigates the acute inflammatory response in the liver and vasculature following injury from trauma/hemorrhagic shock, sepsis, or direct vascular injury. Much of the work has focused on the role of gaseous signaling molecules, including nitric oxide and carbon monoxide. Specifically, we have been investigating the induction of adaptive signaling pathways and how these molecules regulate mitochondrial responses to these stresses to influence immunity and inflammation.